Monoclonal antibodies that bind or neutralize dengue virus

Details Monoclonal antibodies that bind or neutralize dengue virus Monoclonal antibodies that bind or neutralize dengue virus

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/395 (2006.01) C12N 15/68 (2006.01)

Patent

CA 2548808

The present invention relates to monoclonal antibodies that bind or neutralize dengue type 1, 2, 3, and/or 4 virus. The invention provides such antibodies, fragments of such antibodies retaining dengue virus-binding ability, fully human or humanized antibodies retaining dengue virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

L'invention concerne des anticorps monoclonaux qui se lient ou neutralisent le virus de la dengue de type 1, 2, 3 et/ou 4. L'invention concerne également ces anticorps, des fragments de ces anticorps retenant la capacité de liaison au virus de la dengue, les anticorps humanisés ou entièrement humains retenant la capacité de liaison du virus de la dengue, et des compositions pharmaceutiques contenant ces anticorps. L'invention concerne enfin des acides nucléiques isolés codant les anticorps de l'invention et des cellules hôtes transformées au moyen de ces anticorps, ainsi que des procédés prophylactiques, thérapeutiques et diagnostiques utilisant les anticorps et les acides nucléiques de l'invention.

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