Monoclonal antibodies that bind or neutralize hepatitis b virus

Details Monoclonal antibodies that bind or neutralize hepatitis b virus Monoclonal antibodies that bind or neutralize hepatitis b virus

C - Chemistry, Metallurgy

07

K

C07K 16/08 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) A61P 31/20 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2594922

The present invention relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to hepatitis B virus. The invention provides such antibodies, fragments of such antibodies retaining hepatitis B virus-binding ability, fully human or humanized antibodies retaining hepatitis B virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

L'invention concerne l'isolement et la caractérisation d'un nouvel anticorps monoclonal neutralisant de chimpanzé dirigé contre le virus de l'hépatite B. L'invention concerne également de tels anticorps, des fragments de tels anticorps restant aptes à la liaison avec le virus de l'hépatite B, des anticorps totalement humains ou humanisés restant aptes à la liaison avec le virus de l'hépatite B, ainsi que des compositions pharmaceutiques contenant de tels anticorps. L'invention concerne en outre des acides nucléiques isolés codant les anticorps de l'invention et des cellules hôtes transformées à l'aide de ces acides nucléiques. Enfin, l'invention concerne des méthodes prophylactiques, thérapeutiques et diagnostiques utilisant les anticorps et acides nucléiques selon l'invention.

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