C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61P 11/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2705539
Disclosed herein are anti-hGM-CSF monoclonal antibodies and antigen-binding fragments of such antibodies, with improved neutralizing capacity to hGM-CSF activity. Pharmaceutical compositions comprising such an antibody or antigen-binding fragment are also provided. The present invention is useful for the treatment of various diseases that are associated with aberrant expression of hGM-CSF.
La présente invention concerne des anticorps monoclonaux anti-hGM-CSF et des fragments de liaison à un antigène de tels anticorps, dotés d'une capacité de neutralisation améliorée de l'activité du hGM-CSF. L'invention concerne également des compositions pharmaceutiques comprenant un tel anticorps ou un tel fragment de liaison à un antigène. La présente invention est utile pour le traitement de diverses maladies qui sont associées à une expression aberrante du hGM-CSF.
Kistler Barbara
Nakajima Kantou
Park John
Takada Kenzo
Boehringer Ingelheim International Gmbh
Evec Inc.
Smart & Biggar
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