C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 35/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2110852
MONOCLONAL ANTIBODIES THAT DEFINE A UNIQUE ANTIGEN OF HUMAN B CELL RECEPTOR COMPLEX AND METHODS OF USING SAME FOR DIAGNOSIS AND TREATMENT Abstract of the Invention Three monoclonal antibodies defining extracellular epitopes of a unique heterodimeric glycoprotein complex consisting of the human mb-1 protein and the human B29 protein which react with one or more leukemia lymphoma cell specimens selected from the group consisting of B prolymphocytic leukemia cells, B non-Hodgkin's lymphoma cells, B chronic lymphocytic leukemia cells, B hairy cell leukemia cells, and B acute lymphoblastic leukemia cells. The three monoclonal antibodies also react with human non- malignant B cells. The invention also provides a method for producing the new monoclonal antibodies and for diagnostic procedures using the new monoclonal antibodies to detect various leukemias and lymphomas, as well as describing methods of using the monoclonal antibodies for the treatment of leukemia-lymphoma patients and patients with immunological diseases. The invention also relates the isolation and chemical identification of the human B29 and mb-1 proteins of B cell antigen receptor complex. The amino-terminal amino acid sequences of the mb-1 and B29 gene products were determined.
Gowling Lafleur Henderson Llp
Health Research Inc.
LandOfFree
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