Monoclonal antibodies to a broad range of mammalian terminal...

Details Monoclonal antibodies to a broad range of mammalian terminal... Monoclonal antibodies to a broad range of mammalian terminal...

C - Chemistry, Metallurgy

12

N

195/1.111

C12N 5/00 (2006.01) C07K 16/40 (2006.01)

Patent

CA 1272455

ABSTRACT Murine monoclonal antibodies specific to unique antigenic determinants on mammalian terminal deoxy- nucleotidyl transferases (TdT). The monoclonal antibodies specifically bind to TdT in a wide variety of mammalian cells including human, mouse, rat, rabbit and bovine origin. The monoclonal antibodies are secreted by hybridoma cells derived from fusion of murine plasmacytoma cells with splenocytes from mice immunized with TdT from bovine thymus cells. The monoclonal antibodies can detect small numbers of TdT- positive cells for monitoring of TdT-positive leukemias and lymphomas in multiple species, including human.

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