C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2180531
The present invention relates to monoclonal antibodies (MAb) to hematopoietic facilitatory cells (FC). In particular, it relates to MAb against antigens expressed by murine FC, methods of generating the antibodies, and methods of using the same, MAb directed to markers that are expressed specifically or at higher levels by FC than by most other bone marrow cells have a wide range of applications, including but not limited to, rapid isolation of FC, identification of FC in a donor cell preparation, and molecular cloning of the genes encoding the corresponding target antigens.
L'invention porte sur des anticorps monoclonaux (MAb) contre des cellules hématopoïétiques (FC) et en particulier sur des MAb agissant contre des antigènes exprimés par les cellules FC de la souris, ainsi que sur leurs méthodes d'obtention et d'utilisation. Les MAb dirigés contre des marqueurs exprimés spécifiquement ou à des niveaux plus élevés par les FC que par la plupart des cellules de moelle osseuse présentent une large gamme d'applications incluant de façon non limitative l'isolement rapide des FC, leur identification dans une préparation de cellules donneuses et le clonage moléculaire des gènes codant les antigènes cibles correspondants.
Colson Yolanda
Ildstad Suzanne T.
Kaufman Christina
Osler Hoskin & Harcourt Llp
University Of Pittsburgh
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