Monoclonal antibodies to fc receptors for immunoglobulin g...

Details Monoclonal antibodies to fc receptors for immunoglobulin g... Monoclonal antibodies to fc receptors for immunoglobulin g...

C - Chemistry, Metallurgy

12

P

167/37, 195/1.11

C12P 21/08 (2006.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1319899

ABSTRACT The invention pertains to monoclonal anti- bodies which are specific for the human high affinity Fc receptor for IgG, the p72 receptor, and which bind to the Fc receptor without being blocked by human IgG. The antibodies bind specifically, through their antigen combining region and independent of their Fc portion, to human receptor for the Fc portion of IgG. The antibodies bind to a site on the Fc receptor distinct from the binding site for the Fc region of IgG (ligand) and the antibodies are capable of binding a ligand-occupied receptor. The anti-Fc receptor antibody according to the invention can be used to produce target-specific effector cells for treatment of cancer, allergies, and infectious and autoimmune diseases.

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