Monoclonal antibodies to gp120 which neutraleze hiv-1

Details Monoclonal antibodies to gp120 which neutraleze hiv-1 Monoclonal antibodies to gp120 which neutraleze hiv-1

C - Chemistry, Metallurgy

12

N

167/140, 195/1.1

C12N 5/16 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339857

Monoclonal antibodies are disclosed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the rate of infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC. Chimeric viral-neutralizing anti-bodies, including chimeric HIV-neutralizing anti-bodies, are also disclosed.

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