Monoclonal antibodies to hiv-1 gp120, cell lines producing...

Details Monoclonal antibodies to hiv-1 gp120, cell lines producing... Monoclonal antibodies to hiv-1 gp120, cell lines producing...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/42 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2099531

ABSTRACT The invention provides monoclonal antibodies to HIV-1, which react witha HIV-1 gpl20 glycoprotein or first variant thereof wherein the amino- acids Asn-88, Lys-117, Asn-262 and Tyr-435 are present, and exhibit an at least 50% reduced reaction with a second variant of said glyco- protein which differs from said glycoprotein or first variant thereof in that one or more of said aminoacids has been deleted or mutated. Furthermore, the invention provides compositions for passive and active immunization based on these antibodies and on anti-idiotype antibodies, respectively; as well as cell lines and processes for producing these antibodies.

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