C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/42 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/08 (2006.01) C12P 21/08 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2282410
The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially inhibit binding of activated leukocyte adhesion molecule (ALCAM) to hCD6. The binding agents of the invention are useful, inter alia, in methods for screening peptides and drugs that also bind to hCD6 and/or modulate ALCAM binding to hCD6, as well as in diagnostic and therapeutic methods for management and treatment of inflammatory and autoimmune diseases.
La présente invention porte sur des anticorps et autres agents liants qui se fixent spécifiquement aux domaines SRCR du CD6 humain (hCD6) et ont des propriétés avantageuses, notamment la capacité d'inhiber de manière substantielle la fixation de la molécule d'adhérence des cellules leucocytes activées (ALCAM) à l'hCD6. Les agents de fixation selon l'invention trouvent des applications utiles, notamment dans les méthodes de dépistage systématique des peptides et drogues qui se fixent aussi à l'hCD6 et/ou modulent l'ALCAM se fixant à l'hCD6, ainsi que dans les méthodes diagnostiques et thérapeutiques pour la gestion et le traitement de maladies inflammatoires et auto-immunes.
Aruffo Alejandro
Bajorath Jurgen
Bodian Dale L.
Bowen Michael A.
Siadak Anthony W.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
Monoclonal antibodies to human cd6 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies to human cd6, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies to human cd6 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1710398