Monoclonal antibodies to human immune interferon

Details Monoclonal antibodies to human immune interferon Monoclonal antibodies to human immune interferon

C - Chemistry, Metallurgy

12

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195/1.108

C12P 21/02 (2006.01) C07K 14/57 (2006.01) C07K 16/24 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1240939

- 22 - ABSTRACT "MONOCLONAL ANTIBODIES TO HUMAN IMMUNE INTERFERON" Disclosed are monoclonal antibody substances specifically immunologically reactive with native and recombinant human immune interferon ("IFN-.gamma.") and with polypeptides having amino acid sequences substantially duplicative of sequences extant in IFN-.gamma.. In a presently preferred embodiment, antibody substances are produced by new mouse-mouse hybridoma tumor cell line A.T.C.C. HB 8291 and are immunoreactive with native IFN-y, with recombinant IFN-.gamma. and polypeptide analogs thereof, and with a nonadecapeptide whose amino acid sequence dupli- cates that of the final nineteen amino acid residues of the carboxyl terminal of IFN-.gamma.. These preferred antibody substances, while displaying high affinity for IFN-.gamma., do not neutralize antiviral biological activity of the interferon. They are usefully employed in the detection, quantification and affinity purification of IFN-.gamma. and IFN-.gamma. analogs as well as in investigations relating to the mode of biological action of IFN-.gamma..

452015

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