Monoclonal antibodies to human plasma prekallikrein and...

Details Monoclonal antibodies to human plasma prekallikrein and... Monoclonal antibodies to human plasma prekallikrein and...

C - Chemistry, Metallurgy

12

P

167/37, 195/1.11

C12P 21/08 (2006.01) C07K 16/40 (2006.01) C12N 5/20 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1312564

MONOCLONAL ANTIBODIES TO HUMAN PLASMA PREKALLIKREIN AND METHODS OF PREPARING AND USING SAME Abstract of the Disclosure Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein, specifically the heavy chain thereof, and kallikrein-Cl-inhibitor complex. The antibodies do not cross-react with tissue kallikrein. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with SP2/O- Ag14 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.

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