Monoclonal antibodies to peptidoglycan and methods of...

Details Monoclonal antibodies to peptidoglycan and methods of... Monoclonal antibodies to peptidoglycan and methods of...

C - Chemistry, Metallurgy

12

N

167/45, 195/1.10

C12N 5/00 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247537

MONOCLONAL ANTIBODIES TO PEPTIDOGLYCAN AND METHODS OF PREPARING SAME Abstract Several novel hybridoma cell lines, ATCC #HB-8510, 8511, 8512, 8513, 8514, 8515, 8516, and 8517 produce mono- clonal antibody to an antigen, peptidoglycan, which is a normal structural component of nearly all true bacteria. Each antibody reacts not only with peptidoglycan from the immunizing bacterial strain but also peptidoglycan from other strains. Certain of the members of the hybridoma panel produce monoclonal antibody which reacts with pep- tidoglycan from substantially any peptidoglycan-possessing bacterium. The hybridomas are formed by fusing spleen cells from immunized Balb/c mice with SP2/O-Ag14 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibodies are provided.

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