C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/140, 167/44,
C12P 21/08 (2006.01) A61K 39/42 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2013517
ABSTRACT OF THE DISCLOSURE Murine monoclonal antibodies are provided which bind specifically to the PreS1 and PreS2 polypeptides of the hepatitis B virus surface antigen (HBsAg) complex and which are useful to assay for PreS1 or PreS2 in samples of physi- ological material. The antibodies can also be used to subtype HBV, to raise the immunogenicity of blood plasma against HBV, to measure anti-PreS1 and anti-PreS2 anti- bodies, and to identify and characterize antigenic epitopes of PreS1 and PreS2 which may be useful in HBV subunit vaccines.
Eble Kim S.
Floreani Marco F.
Mimms Larry T.
Rosenlof Robert V.
Tyner Joan D.
Abbott Laboratories
Goudreau Gage Dubuc
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