Monoclonal antibodies to specific antigenic regions of the...

Details Monoclonal antibodies to specific antigenic regions of the... Monoclonal antibodies to specific antigenic regions of the...

C - Chemistry, Metallurgy

12

N

167/37, 195/1.10

C12N 5/18 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339363

Monoclonal antibodies capable of binding antigenic determinants within regions of the p25 core protein of the Human Immunodeficiency Virus and immortalized cell lines producing those monoclonal antibodies are provided. The monoclonal antibodies find use in a variety of ways, including HIV antigen detection in biological samples. Using these methods, individuals may be identified who are infected with HIV but who have not yet developed anti-HIV antibodies. The methods also find use in monitoring in vitro growth of HIV, and the efficacy of therapeutic agents and vaccines.

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