Monoclonal antibodies to tetracyclic compounds, processes...

Details Monoclonal antibodies to tetracyclic compounds, processes... Monoclonal antibodies to tetracyclic compounds, processes...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/44 (2006.01) C12N 5/12 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2014006

4-17538/= Monoclonal antibodies to tetracyclic compounds, processes for their production, and applications Abstract of the Disclosure The invention concerns monoclonal antibodies directed against R-(-)-oxaprotiline and its metabolite R-(-)-oxaprotiline beta- glucuronide, derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines that secrete the desired monoclonal antibodies, a process for the preparation of such hybridoma cells, kits containing the monoclonal antibodies and/or their derivatives, and the use of the monoclonal antibodies and/or their deri- vatives for the qualitative and quantitative determination of R-(-)-oxa- protiline and R-(-)-oxaprotiline beta-glucuronide and for the treatment of a toxicosis due to an overdose of R-(-)-oxaprotiline.

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