C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 1/00 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2425000
Monoclonal and polyclonal antibodies to the binding subdomains of the MAP protein, including the Map 10 protein, or other immunogenic subregions of the MAP protein, are provided which can be useful in the treatment of and protection against infection from staphylococcal bacteria such as Staphylococcus aureus. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the antibodies of the present invention are advantageous because they serve the double purpose of preventing adherence of the bacteria to host cells and enhancing the killing of the bacteria in an infected host.
L'invention concerne des anticorps monoclonaux et polyclonaux dirigés contre des sous-domaines de liaison de la protéine MAP, y compris la protéine MAP 10, ou d'autres sous-régions immunogènes de la protéine MAP, lesquels anticorps peuvent être utiles dans le traitement et la protection contre une infection causée par des bactéries staphylococciques telles que le Staphylococcusaureus . En outre, des instruments médicaux peuvent êtretraités à l 'aide de ces anticorps afin de diminuer ou d'éliminer la possibilité qu'ils soient infectés ou qu'ils diffusent davantage l'infection. Plus spécifiquement, les anticorps de cette invention sont avantageux car ils remplissent la double fonction consistant à empêcher l'adhérence des bactéries dans des cellules hôtes et à augmenter la mort des bactéries dans un hôte infecté.
Domanski Paul
Patel Pratiksha
Patti Joseph M.
Blake Cassels & Graydon Llp
Inhibitex Inc.
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