C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/139, 167/37
C12N 15/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 1285222
MONOCLONAL ANTIBODIES USEFUL IN THE IDENTIFICATION OF MICROORGANISMS CAUSING PERIODONTAL DISEASE ABSTRACT Actinobacillus actinomycetemcomitans has frequently been implicated in juvenile periodontitis. The present monoclonal antibodies are specific to Actinobacillus actinomycetemcomitans. The present monoclonal antibodies are typically employed as reagents which include an lnert carrier, preferbly a liquid, such as buffered saline solution and a preservative. The carrier compositions are suitably selected to provide for the proper dispersal of bacteria, and to preserve the integrity of antigens and supplemental structures. The selection of the proper carrier is especially important in the detection in mixtures which include bacteria which produce large amounts of autolyltic enzymes such as B. gingivalis. The monoclonal antibodies of the present invention are useful in clinical testing and differentiating antigens in the gingival or subgingival sera. The method of testing and differentiating involves the steps of contacting a sample of the bacterial flora from a lesion or other site with a measured amount of monoclonal antibody specific to a single antigen site on Actinobacillus actinomycetemcomitans and subsequently measuring the number of antibody-antigen complexes formed.
528819
Christersson Lars Anders
Genco Robert Joseph
Neiders Mirdza Erika
Zambon Joseph James
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
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