Monoclonal antibodies which promote central nervous system...

Details Monoclonal antibodies which promote central nervous system... Monoclonal antibodies which promote central nervous system...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/30 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188919

Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelnating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determinants on glial cells.

L'invention concerne des anticorps monoclonaux IgM favorisant la remyélinisation du système nerveux central lorsqu'il sont donnés à un mammifère souffrant d'une maladie démyélinisante. Ces anticorps présentent une autoréactivité multiorgane et ils reconnaissent les déterminants à la fois de surface et cytoplasmiques sur des cellules gliales.

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