G - Physics – 01 – N
Patent
G - Physics
01
N
167/44, 195/1.11
G01N 33/577 (2006.01) C07K 16/18 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01) G01N 33/86 (2006.01)
Patent
CA 1247022
ABSTRACT This invention relates to a method of preparation of monoclonal antibody derived from a crosslinked fibrin derivative including the steps of; (i) obtaining a crosslinked fibrin derivative or extract containing same; and (ii) forming antibody to said derivative or extract by cloning antibody producing cells from an animal having been administered thereto said derivative or extract. There is also provided a screening assay for use in the abovementioned method which includes the steps of: (A) coating a surface with antigen selected from (i) crosslinked fibrin derivative; (ii) extract containing said derivative, or (iii) fibrinogen degradation product. (B) contacting said antigen with monoclonal antibody derived from crosslinked fibrin derivative; and (C) subjecting the complex formed in step (A) to a signal amplification step. There is also provided an assay procedure for detection of the presence of a crosslinked fibrin derivative in an animal body fluid including the steps of: (i) contacting monoclonal antibody prepared from a crosslinked fibrin derivative with a fluid sample suspected of containing an antigen derived from a crosslinked fibrin derivative or comprising a crosslinked fibrin derivative per se; and (ii) subjecting the complex formed in step (i) to a signal amplification step.
449733
Bundesen Peter G.
Rylatt Dennis B.
Mabco Limited
Mccarthy Tetrault Llp
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