Monoclonal antibody 175 targeting the egf receptor and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2696360

The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

La présente invention concerne des anticorps, en particulier l'anticorps 175, et des fragments de celui-ci ou des anticorps dérivés de celui-ci, qui se lient au récepteur EGF, et en particulier au récepteur de facteur de croissance épidermique amplifié ou surexprimé (EGFR) et à la troncation de2-7 EGFR de EGFR. Ces anticorps sont utiles dans le diagnostic et le traitement du cancer. La présente invention concerne également des anticorps recombinants ou hybrides qui présentent la ou les séquences de chaînes lourdes ou légères variables de l'anticorps 175. Les anticorps de la présente invention peuvent également être utilisés en thérapie, en combinaison avec des agents chimiothérapeutiques ou des agents anti-cancéreux et/ou avec d'autres anticorps ou fragments de ceux-ci.

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