Monoclonal antibody against complexed and noncomplexed...

C - Chemistry – Metallurgy – 12 – P

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530/17, 167/44,

C12P 21/08 (2006.01) A61K 39/385 (2006.01) C07K 16/44 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2037664

The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethy- lenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Further- more, these mAB are suitable as components of immuno- assays (RIA, ELISA etc.) for the quantitative determina- tion of EDTA or DTPA in aqueous solutions.

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