Monoclonal antibody against lps core

Details Monoclonal antibody against lps core Monoclonal antibody against lps core

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) C12N 5/18 (2006.01) C12N 15/13 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105979

By use of the Köhler/Milstein procedure involving immunization of mice with a number of different rough strains of heat- killed Gram-negative bacteria followed by fusion and suitable screening of the resulting hybridomas, murine monoclonal antib- odies are obtained which are cross-protective against endotoxemia caused by at least two different Gram-negative bacterial strains having different core structures. The murine MAbs may be chimerized or humanized by known methods. The preferred product is a chimeric MAb of IgG isotype in which the hypervariable regions of the heavy chain have the amino acid sequences: Asp Tyr Tyr Met Thr; Leu Ile Arg Asn Lys Arg Asn Gly Asp Thr Ala Glu Tyr Ser Ala Ser Val Lys; and Gln Gly Arg Gly Tyr Thr Leu Asp Tyr; the hypervariable regions of the light chain have the amino acid sequences: Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser; Lys Ala Ser Asn Leu His Thr; and Leu Gln Gly Gln Ser Tyr Pro Arg Thr; the framework regions in the variable do- mains are murine and the constant domains are human.

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