C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2083399
2083399 9119000 PCTABS00008 A monoclonal antibody showing specific reactivity against the precursor protein named p55 which is cleaved by HIV-1 protease into smaller structural protein. The antibody of this invention shows specific reactivity against an epitope of the p55 protein which corresponds to the cleavage site by HIV-1 protease which generates the p24 and p17 structural proteins. The specific antibody is an IgG1 protein with a molecular weight of the order of 150,000 Dalton produced by a hybridoma deriving from the fusion of spleen cells of animals immunized with a cloned fused protein containing a p55 fragment which includes the p24/p17 cleavage site and a myeloma cell line. The specific antibody is useful for monitoring HIV-1 exposure, for isolation and purification of natural or synthetic peptides containing the p55 sequence or a fragment thereof which include the p24/p17 cleavage site and for screening substances for HIV-1 protease inhibitory activity.
Nolli Maria L. C.
Sarubbi Edoardo G.
Gruppo Lepetit S.p.a.
Smart & Biggar
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