Monoclonal antibody covalently linked to the toxin ricin

Details Monoclonal antibody covalently linked to the toxin ricin Monoclonal antibody covalently linked to the toxin ricin

A - Human Necessities

61

K

167/129, 195/1.1

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1214124

Improved Protocol for the Treatment of Graft Versus Host Disease Abstract This invention relates to a monoclonal antibody known as TA-1 directed against human T-cells and which is covalently linked to the toxin ricin and used to treat human donor bone marrow before the marrow is infused into a human recipient. Additionally, mono- clonal antibodies known as TA-1, T101, and UCHT1 covalently linked to separate ricin toxins, are combined in a mixture and used in an improved protocol in the treatment of human donor bone marrow prior to the infusion of the marrow into a human recipient.

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