Monoclonal antibody directed against the human ldl receptor

Details Monoclonal antibody directed against the human ldl receptor Monoclonal antibody directed against the human ldl receptor

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2661853

The invention relates to a monoclonal antibody directed against the human LDL (Low Density Lipoprotein) receptor, in which the variable region of each of the light chains is coded by the murine nucleic acid sequence SEQ ID NO : 5, the variable region of each of the heavy chains is coded by the murine nucleic acid sequence SEQ ID NO : 7, or by nucleic acid sequences having a sufficient homology with the sequences SEQ ID NO : 5 and SEQ ID NO : 7 so that the nature and the affinity of the bond between the antibody and its antigene are not modified, while the constant regions of the light chains and the heavy chains thereof are constant regions from a non-murine species.

L'invention concerne un anticorps monoclonal dirigé contre le récepteur humain des LDL (Low Density Lipoprotein), dans lequel la région variable de chacune de ses chaînes légères est codée par la séquence d'acide nucléique murine SEQ ID NO : 5, la région variable de chacune de ses chaînes lourdes est codée par la séquence d'acide nucléique murine SEQ ID NO : 7, ou par des séquences d'acide nucléique présentant une homologie suffisante avec les séquences SEQ ID NO : 5 et SEQ ID NO : 7 pour que la nature et l'affinité de la liaison dudit anticorps à son antigène ne soient pas modifiées, et les régions constantes de ses chaînes légères et de ses chaînes lourdes sont des régions constantes provenant d'une espèce non-murine.

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