G - Physics – 01 – N
Patent
G - Physics
01
N
167/37, 195/1.11
G01N 33/53 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 37/00 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1257210
ABSTRACT This invention concerns a new monoclonal antibody (mAb) 4C, recognizing a specific antigen, Leu 200, found in human hematopoietic tissues. The monoclonal antibody precipitates a series of glycoproteins (Leu 200) with a molecular weight range of about 190,000 to 230,000 from both T- and B-cell lines. The series of glycoproteins resolves into four discrete glycoprotein bands, the distribution of which varies according to the cell lines. Bands 3 and 4 predominate in a majority of T-cells whereas band 2 predominates in B cells. Thus, a Leu 200 antigen subset distribution is possible with mAb 4C. Bands 1, 2, 3, 4 have apparent molecular weights of 230K, 215K, 205K, and 90K respectively, with differences in their carbohydrate moieties. mAb 4C is a IgG sub two a,kappa immunoglobulin. 4C has potential use in leukemia, hematopoietic cell differentiation and transplantation diagnoses and therapy.
454984
Collins Nancy
Dupont Bo
Lloyd Kenneth O.
Morishima Yasua
Ogata Shun-Ichiro
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sloan-Kettering Institute For Cancer Research A.k.a. Sloan-Kette
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