G - Physics – 01 – N
Patent
G - Physics
01
N
167/45, 195/1.11
G01N 33/577 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/08 (2006.01) C12P 21/08 (2006.01)
Patent
CA 1294233
ABSTRACT A murine monoclonal antibody which selectively binds to the determinant site or specific epitope of glycophorin A exposed on the membrane of the erythrocyte and does not bind to other glycophorins. The monoclonal antibody is coated on a microsphere or substrate of a suitable monodispersed variety and utilized in a separation procedure for recovery of white blood cell subsets without lysing of erythrocytes. The bound microspheres are recovered without adverse depletion of the white blood cell population of the sample. The microsphere or bead-to-cell ratio employed is most acceptable for commercial applications of the invention. The invention thus enables accurate assaying of white blood cell subsets in circulating peripheral blood without resorting to lysing of erythrocytes.
517986
Hofheinz David E.
Kortright Kenneth H.
Borden Ladner Gervais Llp
Coulter International Corp.
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