Monoclonal antibody fragments having immunosuppressant activity

Details Monoclonal antibody fragments having immunosuppressant activity Monoclonal antibody fragments having immunosuppressant activity

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2206471

The invention comprises monovalent mAb fragments (Fab) of mAb which have the ability of downregulate HLA-DR expression on antigen presenting cells. The Fab fragments can downregulate such HLA-DR expression without the cytotoxicity of the parent mAb or of bivalent fragments (F(ab)'2) of the mAb. The Fab fragments of the invention are therefore potent, class II MHC-specific immunosuppressive compounds without cytotoxic side effects.

L'invention porte sur des fragments mAb monovalents (Fab) de mAb qui sont capables de d'atténuer l'expression HLA-DR sur les cellules présentatrices de l'antigène, Les fragments FAB peuvent atténuer cette expression de HLA-DR sans la toxicité des fragments mAb apparentés ou de fragments bivalents (F(ab)'2) du mAb. Les fragments Fab de l'invention sont donc des composés immunosuppresseurs spécifiques du CMH de classe II qui n'ont pas d'effets secondaires cytotoxiques.

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