C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/32 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2472383
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met and its agonist ligand HGF. Disclosed herein are (a) mAbs and hybridoma cell lines that produce them, which mAbs antibodies are specific for Met and (b) combinations of anti-Met and anti-HGF mAbs. When detectably labeled, these antibodies are useful for imaging such tumors. Anti-Met mAb compositions and methods for scintigraphic detection, diagnosis, prognosis, monitoring and therapy of Met-bearing tumors are provided.
Dans un grand nombre de tumeurs solides humaines, un phénotype métastatique agressif et un pronostic clinique défavorable sont associés à l'expression du récepteur tyrosine kinase Met et de son ligand agoniste HGF. L'invention concerne : (a) les anticorps mAbs et les lignées cellulaires du type hybridome qui produisent ces derniers, lesquels mAbs sont spécifiques de Met ; et (b) des combinaisons de mAbs anti-Met et anti-HGF. Lorsqu'ils sont marqués de manière détectable, ces anticorps sont utiles pour la mise en image desdites tumeurs. L'invention concerne également des compositions mAb anti-Met et des méthodes destinées à la détection scintigraphique, au diagnostic, au pronostic, à la surveillance et au traitement de tumeurs porteuses de Met.
Cao Boliang
Gross Milton D.
Hay Rick V.
Resau James H.
Vande Woude George F.
Cao Boliang
Gross Milton D.
Hay Rick V.
Resau James H.
Smart & Biggar
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