Monoclonal antibody inducing apoptosis

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01)

Patent

CA 2303072

A monoclonal antibody which is an antibody specifically recognizing human integrin associated proteins and is an antigen inducing the apoptosis of nucleated blood cells having the human integrin associated proteins. Therefore, it is useful as an antibody, which specifically recognizes the human integrin associated proteins, in discriminating and identifying these proteins. Owing to the effect of inducing the apoptosis of nucleated blood cells, the above antibody is also usable as remedies, etc. in the fields of, for example, treating myelocytic leukemia and lymphatic leukemia.

Cette invention concerne un anticorps monoclonal qui consiste en un anticorps reconnaissant spécifiquement les protéines associées à l'intégrine humaine, et qui est un antigène capable d'induire l'apoptose de cellules sanguines nucléées comportant des protéines associées à l'intégrine humaine. Il peut ainsi être utilisé en qualité d'anticorps reconnaissant spécifiquement les protéines associées à l'intégrine humaine lors du tri et de l'identification de ces protéines. Etant donné qu'il permet d'induire l'apoptose de cellules sanguines nucléées, cet anticorps peut également être utilisé comme médicaments, par exemple lors du traitement de la leucémie myélocytaire et de la leucémie lymphatique.

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