Monoclonal antibody kc-57 to hiv core proteins

Details Monoclonal antibody kc-57 to hiv core proteins Monoclonal antibody kc-57 to hiv core proteins

C - Chemistry, Metallurgy

12

N

195/1.105

C12N 5/16 (2006.01) C07K 16/10 (2006.01)

Patent

CA 1339350

A hybridoma cell line is provided which produces a novel monoclonal antibody which binds to selective major HIV core proteins. This novel monoclonal antibody recognizes a common epitope of certain HIV core antigens in a reliable and consistant manner so that the antibody can be used in immunoassays to track HIV viral antigens in human physiological serum samples. The monoclonal antibody, identified herein as KC-57, binds to an HIV antigen on the core protein p55 which is the precursor protein for the gag gene, the core protein p24 and the partial breakdown proteins p33 and p39. The KC-57 monoclonal antibody does not bind to the p18 core protein or any HIV envelope protein.

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