Monoclonal antibody pd41 and antigen associated with...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 5/18 (2006.01) C12N 15/12 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106487

2106487 9314775 PCTABS00024 Monoclonal antibodies that bind specifically to prostate carcinoma and do not bind substantially to normal prostate or benign prostatic hyperplasia, as well as hybridoma cell lines producing the monoclonal antibodies are disclosed. In one embodiment, a monoclonal antibody designated MAb PD41 is disclosed. A new antigen designated prostate mucin antigen is disclosed in isolated, substantially pure form. In addition, methods for using the hybridoma cell lines, the monoclonal antibody and/or the antigen for diagnosis, prophylaxis and/or treatment of prostate carcinoma are disclosed.

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