C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/1.109
C12P 21/08 (2006.01) C07K 16/30 (2006.01) C12N 5/20 (2006.01)
Patent
CA 1306428
MONOCLONAL ANTIBODY SPECIFIC FOR A MAMMARY TUMOR CELL SURFACE ANTIGEN ABSTRACT OF THE DISCLOSURE A monoclonal antibody is produced which is specific for a cell surface antigen found predominantly on human mammary tumor cells. Animals are inoculated with human mammary tumor cells or cell material, and spleen cells obtained from the animals are fused with myeloma cells to produce hybridomas. The hybridomas are cultured as monoclones, and antibodies obtained from the individual clones are tested for their reactivity with several human mammary tumor cell lines and mammary tumor tissues. A clone which produces an antibody that reacts generally with human mammary tumor cells but not other tumors, such as mesotheliomas, is selected for further culturing to produce the antibody, and the antibody is obtained from the culture growth medium or from ascitic fluid of an animal bearing a tumor of the hybridoma. The antibody is useful in diagnosing mammary tumors.
496242
Allen William R.
Dulbecco Renato
White Christine A.
Allen William R.
Dulbecco Renato
Macrae & Co.
The Salk Institute For Biological Studies
White Christine A.
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