C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C12N 5/20 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2212887
The instant invention provides for monoclonal antibody which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43" and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
Cette invention se rapporte à un anticorps monoclonal qui est spécifique du peptide beta A4, et en particulier de la terminaison C libre de ce peptide "1-42" mais non "1-43", et qui colore l'amyloïde diffuse et fibrillaire, l'amyloïde vasculaire et les enchevêtrements neurofibrillaires. Cette invention se rapporte en outre à des fragments de cet anticorps et à des constructions de ceux-ci, qui ont la même spécificité de liaison. Cette invention décrit également des procédés de diagnostic, de triage et de thérapie, pour le traitement de formes uniques de ce peptide beta A4, au moyen des anticorps de cette invention.
Graham Paul
Konig Gerhard
Corporation Bayer
Janssen Alzheimer Immunotherapy
Smart & Biggar
Wyeth
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