C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2067244
Monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The antibodies are useful for targeting human effector cells (e.g: macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). For this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.
L'invention concerne des anticorps monoclonaux qui réagissent de manière spécifique au récepteur Fc pour IgA de cellules effectrices humaines. Les anticorps sont utiles pour cibler des cellules effectrices humaines (p. ex. des macrophages) contre une cellule cible (p. ex. une cellule cancéreuse, un agent infectieux, etc). A cet effet des anticorps bifonctionnels ou des hétéroanticorps peuvent être construits, lesquels contiennent la région de liaison dérivée d'un anticorps récepteur anti-Fc-alpha et la région de liaison d'un anticorps spécifique à la cible. Les cellules effectrices ciblées peuvent effectuer la lyse spécifique des cellules cibles.
Fanger Michael W.
Shen Li
LandOfFree
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