C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) C07K 14/75 (2006.01) C07K 16/18 (2006.01) C07K 16/36 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2264275
Provided are a monoclonal antibody making it possible to detect a native fibrin monomer, which are produced at the initial state of blood coagulation, and soluble fibrin; a hybridoma; and an immunoassay for assaying the initial stage of blood coagulation highly sensitively, and promptly, using the monoclonal antibody. Using a fibrinogen analogous compound in blood as an immune source, cell fusion is carried out to prepare a monoclonal antibody which is not reactive with fibrinogen and is specifically and simultaneously reactive with a native fibrin monomer (that is, a fibrin monomer which is present in a body fluid, in particular in blood, and is not solubilized) and soluble fibrin. The fibrin monomer analogous compound is preferably fibrinogen treated with bathroxobin, which is a snake venom.
L'invention porte: sur un monomère de fibre naturelle se formant dans les premiers stades de la coagulation sous l'action de thrombine active; sur un anticorps monoclonal permettant de détecter la fibrine soluble; sur des hybridomes; et sur un procédé d'immuno-essai permettant de détecter rapidement et avec une grande sensibilité à l'aide du susdit anticorps les premiers stades de la coagulation. Le monomère de fibre naturelle, qui ne réagit pas avec le fibrinogène (par exemple l'un des monomères non solubilisés de fibrine présents dans les fluides corporels tels que le sang) et l'anticorps monoclonal sont obtenus par un procédé de fusion de cellules recourant à un analogue de monomère de fibrine présent dans le sang en tant qu'immunogène. Le monomère analogue de fibrine décrit ci-dessus sera de préférence du fibrinogène traité à la bathroxobine (venin de serpent).
Hamano Akiei
Tanaka Seiji
Umeda Mamoru
Marks & Clerk
Nissui Pharmaceutical Co. Ltd.
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