Monoclonal antibody to candida albicans cytoplasmic antigens...

Details Monoclonal antibody to candida albicans cytoplasmic antigens... Monoclonal antibody to candida albicans cytoplasmic antigens...

C - Chemistry, Metallurgy

12

P

167/139, 167/37,

C12P 21/00 (2006.01) C07K 14/37 (2006.01) C07K 16/14 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 1251747

MONOCLONAL ANTIBODY TO CANDIDA ALBICANS CYTOPLASMIC ANTIGENS AND METHODS OF PEPARING SAME Abstract Two novel hybridoma cell lines, ATCC #HB-8397 and ATCC #HB-8398 produce monoclonal antibody monospecific to a single determinant shared by a set of three closely related cytoplasmic antigens of Candida albicans. The antigens have molecular weights of 120-135 Kd, 48-52 Kd, and 35-38 Kd. The hybridomas are formed by fusing splenocytes from immunized BALB/c mice with SP2/O-Ag 14 myeloma cells. Monoclonal and monospecific, polyclonal antibodies to these cytoplasmic antigens find application in the immunodiag- nosis of Candida infections. A procedure is provided for preparing partially purified cytoplasmic antigen of pathogenic Candida species for administration to splenocyte-donating mice. Also provided is a method for the biochemical purification of cytoplasmic antigen of a pathogenic Candida species used for the preparation of monoclonal and monospecific, polyclonal antisera thereto.

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