C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/18 (2006.01) C12N 9/52 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250579
The invention relates to an anti-CEA monoclonal antibody (named "806.077 antibody") of murine origin and useful for the diagnosis and therapy of cancer. The antibody complementarity determining regions (CDRs) have the following sequences: heavy chain; CDR1 DNYMH, CDR2 WIDPENGDTE YAPKFRG, CDR3 LIYAGYLAMD Y; and light chain CDR1 SASSSVTYMH, CDR2 STSNLAS, CDR3 QQRSTYPLT. Humanised antibodies are described. The antibody is preferably in the form of a conjugate with either an enzyme suitable for use in an ADEPT system, especially a carboxypeptidase, or with a co-stimulatory molecule such as the extracellular domain of human B7.1.
La présente invention porte sur un anticorps monoclonal anti-antigène carcinomembryonique (CEA) (appelé "anticorps 806.077") d'origine murine, utile pour le diagnostic et le traitement du cancer. Les zones déterminant la complémentarité de cet anticorps comprennent les séquences suivantes: chaîne lourde CDR1 DNYMH, CDR2 WIDPENGDTE YAPKFRG, CDR3 LIYAGYLAMD Y; et chaîne légère CDR1 SASSSVTYMH, CDR2 STSNLAS, CDR3 QQRSTYPLT. La présente invention porte sur des anticorps humanisés. L'anticorps saura de préférence la forme d'un conjugué avec soit une enzyme apte à être utilisée dans un système de traitement par promédicament à base d'enzyme dirigée contre les anticorps (ADEPT), en particulier une carboxypeptidase, soit une molécule costimulante telle que la molécule B7.1 humaine et son domaine extracellulaire.
Copley Clive Graham
Edge Michael Derek
Emery Stephen Charles
Smart & Biggar
Zeneca Limited
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