Monoclonal antibody to endothelin-3 or precursor thereof and...

Details Monoclonal antibody to endothelin-3 or precursor thereof and... Monoclonal antibody to endothelin-3 or precursor thereof and...

C - Chemistry, Metallurgy

12

P

167/44, 195/1.11

C12P 21/08 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2021779

TITLE: MONOCLONAL ANTIBODY TO ENDOTHELIN-3 OR PRECUSOR THEREOF AND USE THEREOF ABSTRACT Disclosed are a monoclonal antibody having an affinity for endothelin-3 or a precursor thereof; a hybridoma cell which produces the monoclonal antibody; and an immunoassay of endothelin-3 and big endothelin-3, a precursor of endothelin-3, by a sandwich method or a competitive method. The monoclonal antibodies can be used as strong antagonists for endothelin-3 in various endothelin-3-related diseases, and the immunoassays make it possible to determine endothelin-3 and big endothelin-3 with high sensitivity.

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