Monoclonal antibody to human beta 2 integrin alpha subunit

Details Monoclonal antibody to human beta 2 integrin alpha subunit Monoclonal antibody to human beta 2 integrin alpha subunit

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218755

DNA encoding a novel human .beta.2 integrin .alpha. subunit polypeptide, designated .alpha.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which include extracellular .alpha.d protein fragments, .alpha.d I domain fragments or full length .alpha.d polypeptides and human immunoglobulin constant regions. Binding molecules specific for .alpha.d are also disclosed as useful for modulating the biological activities of .alpha.d. DNA from other species which show homology to human .alpha.d encoding sequences are also disclosed. Monoclonal antibodies immunospecific for .alpha.d are also disclosed.

On divulgue un ADN codant un nouveau polypeptide de la sous-unité alpha de l'intégrine beta humaine, ledit polypeptide étant appelé alpha d, ainsi que des procédés et des matières permettant sa production par des techniques de recombinaison. On divulgue également des protéines hybrides comprenant des fragments de protéines de alpha d extracellulaires, des fragments du domaine I de alpha d, ou des polypeptides alpha d entiers et des régions constantes de l'immunoglobuline humaine. En outre, on divulgue des molécules de liaison spécifiques du alpha d dont on a mis en évidence qu'elles permettent de moduler les activités biologiques du alpha d. Par ailleurs, on divulgue de l'ADN d'autres espèces présentant une certaine homologie avec les séquences codant le alpha d humain.

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