G - Physics – 01 – N
Patent
G - Physics
01
N
167/139, 167/37,
G01N 33/577 (2006.01) C07K 16/30 (2006.01) C12N 5/00 (2006.01)
Patent
CA 1241610
ABSTRACT Mouse monoclonal antibodies to several cell antigens of human ovarian, cervical and endometrial carcinomas have been produced and characterized. The distribution of the antigens was determined by mixed hemagglutination assays on 153 normal and malignant cell cultures of various types, and by immunoperoxidase staining of frozen sections of 27 normal adult and 24 fetal tissues. five monoclonal antibodies representative of five classes of mAb raised to restricted ovarian, cervical and endometrial cells were tested extensively producing mAb reactive with cancer but not normal cells. One such mAb, MF116 was readily detected in the spent culture medium of metabolically radiolabeled cells. These antibodies, reacting with relatively restricted cell surface antigens, are useful in the analysis of epithelial cell differentiation, in cancer diagnosis and therapy and in tissue typing of normal or abnormal cells.
466619
Cordon-Cardo Carlos
Lewis John L. Jr.
Lloyd Kenneth O.
Mattes M. Jules
Old Lloyd J.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sloan-Kettering Institute For Cancer Research A/k/a Sloan-Kettering Institute
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