C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C12N 5/20 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2715103
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
Dans une grande diversité de tumeurs solides humaines, un phénotype métastatique, agressif et un pronostic clinique médiocre sont associés à l'expression du récepteur tyrosine kinase Met. L'invention porte sur (a) un anticorps monoclonal appelé Met4, lequel anticorps est spécifique pour Met, et (b) une lignée cellulaire d'hybridome qui produit Met4. L'anticorps Met4 est particulièrement utile pour détecter Met dans un tissu fixé au formaldéhyde. L'invention porte sur des procédés d'utilisation de l'anticorps Met4 pour la détection, le diagnostic, le pronostic et l'évaluation d'un rendement thérapeutique.
Cao Boliang
Knudsen Beatrice S.
Vande Woude George F.
Zhao Ping Xu
Fred Hutchinson Cancer Research Center
Mbm Intellectual Property Law Llp
Van Andel Research Institute
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