Monoclonal antibody which is specific for activated...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/36 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C07K 16/46 (2006.01) C12N 9/64 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2259724

A monoclonal antibody has been developed which only specifically binds activated factor VII, and not factor VII, and which does not bind to an activated factor VII which is complexed with antithrombin III. This monoclonal antibody is isolated from the hybridoma cell line DSM ACC 2332. It can be used for qualitatively and quantitatively detecting factor VIIa in body fluids, blood coagulation preparations or the intermediate stages in the production of these preparations, on cell surfaces or in tissues, and can also be used as a humanized monoclonal antibody in therapeutic preparations.

Un anticorps monoclonal a été mis au point, qui lie spécifiquement le facteur VII activé, qui ne lie pas le facteur VII non activé, et qui ne lie pas un facteur VII activé complexifié avec de l'antithrombine III. Cet anticorps monoclonal est produit par la lignée cellulaire d'hybridome DSM ACC 2332. Il peut être utilisé sur des surfaces cellulaires ou dans des tissus pour mettre en évidence qualitativement ou quantitativement le facteur VIIa dans des liquides organiques, des préparations de coagulation sanguine ou dans les étapes intermédiaires de leur préparation, et il peut également être utilisé dans des préparations thérapeutiques contenant l'anticorps monoclonal humanisé.

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