Monoclonal antiidiotypic antibodies (ab2) and their uses

Details Monoclonal antiidiotypic antibodies (ab2) and their uses Monoclonal antiidiotypic antibodies (ab2) and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210705

The present invention is related to the field of Immunology and in particular to the selection and use of antidiotypic monoclonal antibodies (AB2) IgG type with the main characteristic of being highly connected to the idiotipic network and recognition of B and T human lymphocytes, which are major participants in the immune response. According to the previous statement the objective of this invention is to provide antidiotypic monoclonal antibodies IgG type connected to the immune network, able to interact with T and B lymphocytes and able to exert an immunoregulatory effect, immunostimulation or immunosupression that can be used for immunotherapy of autoimmune diseases, infectious diseases and cancer. The essence of the invention consists in generate, produce and select antidiotypic monoclonal antibodies IgG type, idiotipically connected to the immune network, able to recognize B and T human lymphocytes, showing a biological effect in different animal models and selecting those which have shown an "in vivo" effect for the immunotherapy of autoimmune diseases, infectious diseases and cancer.

Anticorps monoclonaux antiidiotipiques de type IgG associés au système immunitaire, pouvant intéragir avec les lymphocytes T et B et exercer un effet immunorégulateur, une immunostimulation ou une immunosuppression pouvant être utilisés en immunothérapie de maladies auto-immunes, infectieuses et du cancer.

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