Monoclonal human natural antibodies

Details Monoclonal human natural antibodies Monoclonal human natural antibodies

C - Chemistry, Metallurgy

12

N

C12N 5/28 (2006.01) A61K 39/42 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2310888

Disclosed herein are hydridoma cell lines producing monoclonal human natural IgM antibodies and methods of use thereof. The antibodies are the monoclonal equivalents of circulating human natural antibodies. Also disclosed herein are pharmaceutical formulations and methods for treating HIV-1 infected individuals using the monoclonal human natural antibodies.

L'invention concerne des lignées cellulaires d'hybridomes produisant des anticorps IgM monoclonaux naturels humains, et leurs procédés d'utilisation. Ces anticorps sont les équivalents monoclonaux des anticorps circulants naturels humains. L'invention concerne également des préparations pharmaceutiques et des procédés de traitement d'individus infectés par le VIH-1 à l'aide de ces anticorps monoclonaux naturels humains.

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