Monocyclic and bicyclic compounds and methods of use

Details Monocyclic and bicyclic compounds and methods of use Monocyclic and bicyclic compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 263/58 (2006.01) A61K 31/496 (2006.01) A61K 31/536 (2006.01) A61K 31/5377 (2006.01) C07D 209/34 (2006.01) C07D 211/14 (2006.01) C07D 233/32 (2006.01) C07D 235/26 (2006.01) C07D 263/22 (2006.01) C07D 265/18 (2006.01) C07D 265/36 (2006.01) C07D 295/185 (2006.01) C07D 413/10 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2618844

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Composés agissant comme puissants agonistes vis-à-vis du récepteur CCR1, et présentant une activité anti-inflammatoire in vivo. Ces composés sont généralement monocycliques et bicycliques, et ils sont utiles dans les conditions suivantes : intégrés à des compositions pharmaceutiques, associés à la mise en oeuvre de procédés de traitement de maladies dont la médiation est assurée par le récepteur CCR1, et aussi comme témoins en liaison avec des essais qui se rapportent à l'identification d'antagonistes compétitifs vis-à-vis du récepteur CCR1.

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