C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61P 25/06 (2006.01) C07D 403/12 (2006.01) C07D 471/20 (2006.01)
Patent
CA 2680307
The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Cette invention a trait à des composés de formule I (les variables A1, A2, B, J, K, m, n, R4, R5a, R5b et R5c étant telles que définies dans la description) utilisés comme antagonistes des récepteurs CGRP et servant à traiter ou à prévenir les maladies dans lesquelles le récepteur CGRP est impliqué, par exemple le mal de tête, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, et l'utilisation de ces composés et compositions pour prévenir ou traiter ces maladies dans lesquelles le récepteur CGRP est impliqué.
Bell Ian M.
Selnick Harold G.
Stump Craig A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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