Monocyclic l-nucleosides, analogs and uses thereof

Details Monocyclic l-nucleosides, analogs and uses thereof Monocyclic l-nucleosides, analogs and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 15/20 (2006.01) A61K 31/70 (2006.01) C07H 19/00 (2006.01) C07H 19/02 (2006.01) C07H 19/04 (2006.01) C07H 19/044 (2006.01) C07H 19/048 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01) C07H 19/06 (2006.01) C07H 19/12 (2006.01)

Patent

CA 2267279

Novel monocyclic L-nucleoside compounds have general formula (I). Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel compounds show immunomodulatory activity, and are expected to be useful in modulating the cytokine pattern, including modulation of Th1 and Th2 response.

La présente invention concerne de nouveaux composés de L nucléoside monocyclique de la formule générale (I): Les réalisations de ces composés sont particulièrement utiles dans le traitement d'une grande variété de maladies incluant des infections, des infestations, des néoplasmes et des maladies auto-immunes. En termes de mécanisme, des réalisations de nouveaux composés montrent une activité immunomodulatrice et on espère qu'elles seront utiles dans la modulation du modèle de cytokine, dont la modulation des réponses Th1 et Th2.

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