Monocyte chemotactic protein-5 materials and methods

Details Monocyte chemotactic protein-5 materials and methods Monocyte chemotactic protein-5 materials and methods

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 5/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250576

The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated MCP-5. Also provided are purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production thereof. These products are useful in therapeutic, diagnostic and medical imaging applications.

L'invention concerne des séquences de polynucléotides purifiées et isolées codant une nouvelle chimiokine C-C humaine dérivée de macrophages, désignée par le symbole MCP-5. L'invention porte également sur une protéine de chimiokine purifiée et isolée, des fragments et des analogues polypeptidiques de celle-ci, des anticorps de ladite protéine et des matériels et des procédés permettant sa fabrication par recombinaison. Ces produits ont des applications thérapeutiques, diagnostiques et peuvent être utilisés en imagerie médicale.

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